Hap Python Remote Debugger
   A remote debugger and IDE that can also be used for local debugging.
   http://hapdebugger.sourceforge.net/

IPython
   An enhanced interactive Python shell with many features for object introspection, system shell access, and its own special command system for adding functionality when working interactively. [Open Source, LGPL]
   http://ipython.scipy.org/

PyCrust - The Flakiest Python Shell
   An interactive, graphical Python shell written in Python using wxPython.
   http://sourceforge.net/projects/pycrust/

Pymerase
   A tool intended to generate a python object model, relational database, and an object-relational model connecting the two using UML or XML. However, it has been extended to also output GUI widgets and can be easily extended to output whatever else you mig
   http://pymerase.sourceforge.net/

Tixapps Applications Framework
   Tixapps applications are a suite of development applications that run with Tk/Tcl or Python, using the Tix widget set. [Open Source, BSD-like]
   http://tix.sourceforge.net/Tixapps/

Winpdb
   An advanced python debugger, with support for smart breakpoints, multiple threads, namespace modification, embedded debugging and encrypted communication.
   http://www.digitalpeers.com/pythondebugger/